Two Dose Epidural Morphine for Post-cesarean Analgesia
Stopped early · Phase 4
Conditions studied: Pain, Morphine Adverse Reaction
In brief
The investigators aim to assess the analgesic effect of a two-dose epidural morphine regimen for 2nd day post-cesarean pain, as part of a multimodal analgesia regimen, which includes scheduled Nonsteroidal anti-inflammatory drugs (NSAIDs). The investigators hypothesize that administration of a second dose of epidural morphine 3 mg, 24 hours after an initial intraoperative dose, will provide superior post-cesarean analgesia during the 2nd 24 hours after surgery, compared to a single epidural morphine dose regimen. The primary outcome will be the amount of intravenous morphine patients self-administer during the 2nd 24 hours post-surgery.
Key facts
- Study ID
- NCT01844206
- Run by
- Columbia University
- People needed
- 5
- Starts
- 2013-06-01
- Expected to finish
- 2014-06-01
- Last updated by the study team
- 2015-12-23
Who can join
Age: 18 and older, up to 45. Sex: female. Healthy volunteers: not accepted.
You may qualify if…
- Women undergoing cesarean section under epidural anesthesia.
You may not qualify if…
- Emergent cesarean section
- Coagulopathy
- Failed epidural anesthesia or patchy block
- General anesthesia
- Use of epidural chloroprocaine
- Allergy or contraindication to Non-steroidal anti-inflammatory drug (NSAIDs)
- Severe opioid side effects
- History of chronic opioid use
- History of chronic pain
- History of obstructive sleep apnea
- Morbid obesity (Body Mass Index (BMI)>45 kg/m2)
- Height under 4' 10" (147 cm)
- Documented dural puncture by the epidural (Tuohy) needle
- Preeclampsia
- Other significant medical disease (American Society of Anesthesiologists (ASA) 3 or more).
Where it is running
- New York Presbyterian Hospital — New York, New York, United States
Full record on ClinicalTrials.gov
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