Endogenous Pain Facilitation and Inhibition in Postpartum Women

Completed

Conditions studied: Pain Inhibition and Facilitation in Post Partum Women

In brief

This study seeks to further understand these three observations - (1) that the time period surrounding childbirth accelerates recovery from pain after injury (2) that this likely reflects dampened facilitating mechanisms and exaggerated inhibitory mechanisms, and (3) that stress may interfere with this protection. In this study the investigators will compare women within 2 weeks of delivery to age matched controls and anticipate that pain inhibition is increased after delivery, pain facilitation is decreased, and that there is a relationship between these pain responses and the degree of pre-existing stress.

Key facts

Study ID

NCT01843517

Run by

Wake Forest University

People needed

80

Starts

2013-04-01

Expected to finish

2017-12-05

Last updated by the study team

2017-12-19

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• female
• 10-14 days postpartum, term vaginal delivery
• breastfeeding (postpartum women)
• health non-pregnant female (nulliparous or at least 1 year beyond delivery)

You may not qualify if…

• Allergy to chili peppers
• pregnant
• pain medication (narcotic or non-narcotic) within 4 hours of study visit Average pain in the 24 hours preceding the study visit >3. Postpartum women that score >13 on the Edinburgh Postnatal Depression Scale

Where it is running

• Wake Forest Baptist Medical Center — Winston-Salem, North Carolina, United States

Full record on ClinicalTrials.gov

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