Comparing Complete Remission After Treatment With Selumetinib/Placebo in Patient With Differentiated Thyroid Cancer

Stopped early · Phase 3 · Has a placebo group

Conditions studied: Differentiated Thyroid Cancer

In brief

The study is designed to evaluate the clinical efficacy, safety and tolerability of selumetinib with radioactive iodine therapy in patients with differentiated thyroid cancer.

Key facts

Study ID

NCT01843062

Run by

AstraZeneca

People needed

233

Starts

2013-08-27

Expected to finish

2019-03-06

Last updated by the study team

2019-08-28

Who can join

Age: 18 and older, up to 130. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Differentiated thyroid cancer Tumor >4 cm, or Gross extra-thyroid extension, or 1 lymph node >1 cm, or 5 or more lymph nodes of any size Previous thyroidectomy Must be able to receive radioactive iodine therapy Must be able to receive Thyroid Stimulating Hormone suppression

You may not qualify if…

• Metastaic disease Anaplastic thyroid cancer, medullary thyroid cancer or Hurthle cell carcinoma Presence of anti-Tg antibodies Previous treatment with any radiation Unresolved toxicity ≥ common terminology criteria for adverse event Grade 2

Where it is running

• Research Site — Birmingham, Alabama, United States
• Research Site — Little Rock, Arkansas, United States
• Research Site — Los Angeles, California, United States
• Research Site — Torrance, California, United States
• Research Site — Aurora, Colorado, United States
• Research Site — Washington D.C., District of Columbia, United States
• Research Site — Boston, Massachusetts, United States
• Research Site — Boston, Massachusetts, United States
• Research Site — New York, New York, United States
• Research Site — New York, New York, United States
• Research Site — Durham, North Carolina, United States
• Research Site — Cincinnati, Ohio, United States
• Research Site — Portland, Oregon, United States
• Research Site — Philadelphia, Pennsylvania, United States
• Research Site — Nashville, Tennessee, United States
• Research Site — Barretos, Brazil
• Research Site — Porto Alegre, Brazil
• Research Site — Ribeirão Preto, Brazil
• Research Site — Rio de Janeiro, Brazil
• Research Site — São José do Rio Preto, Brazil
• Research Site — São Paulo, Brazil
• Research Site — Odense C, Denmark
• Research Site — Angers, France
• Research Site — Bordeaux, France
• Research Site — Caen, France

Full record on ClinicalTrials.gov

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