The Acute Effects of Passive Vibration on Cardiovascular Function in Individuals With Stroke

Completed · Not applicable

Conditions studied: Stroke, Hemiparesis, Pre-Hypertension, Hypertension

In brief

Stroke is the third leading cause of death in the United States. Of those who are affected by stroke, a third becomes permanently disabled. Risk factors for stroke include, but are not limited to, advancing age, physical inactivity, arterial stiffness, and most commonly, high blood pressure. Stroke is a major form of a much boarder problem, cardiovascular disease (CVD). CVD is considered the primary cause of death in the US. Interestingly, increased arterial stiffness of elastic arteries (carotid and aorta) has been shown to be strongly correlated to CVD and stroke. Increased arterial stiffness is considered an independent risk for the development of CVD and stroke. Hence, arterial stiffness has been suggested as a potential therapeutic target for CVD and more specifically stroke. Recently, whole-body vibration (WBV) exercise has been proposed as a new and effective method to improve muscle mass and muscle strength in younger and older individuals. It is known that systemic arterial stiffness decreased 40 min after a single WBV session in healthy men. In our laboratory, we have shown that leg arterial stiffness decreases after a session of WBV. Taken together, this data seems to suggest WBV may be used as a viable way to decrease arterial stiffness. Special populations, such as post-stroke patients, may be unwilling or unable to perform WBV exercise so an inactive form of exercise (vibration) therapy is needed. Passive vibration (PV), allows patients to lie in an inactive, supine position, with their legs placed onto the vibration plate. This exposes the lower limbs to continuous vibration without performing voluntary muscle contraction. PV has been shown to increase skin blood flow on the vibrated extremity through vasodilation in healthy individuals and type 2 diabetics. Previous work in our laboratory has demonstrated that a 10-min session of PV on the legs decreases augmentation index (AIx) , a marker of pressure wave reflection, as well as leg and systemic PWV through decreases in local peripheral resistance in young men. However, the effects of PV on arterial function in post-stroke patients are unknown. It is hypothesized that post-stroke patients will demonstrate a decrease in leg PWV and central AIx. However, greater responses are expected with the lower vibration frequency.

Key facts

Study ID

NCT01841840

Run by

Florida State University

People needed

11

Starts

2012-01-01

Expected to finish

2012-07-01

Last updated by the study team

2013-04-29

Who can join

Age: 40 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 40-80 years of age
• Resting Blood Pressure between 120/80 and 159/99
• Non-Smoker
• Sedentary or low activity (<120 min per week)
• 25-39.9 kg/m2 BMI
• Diagnosed with stroke for at least 4 months

You may not qualify if…

• Younger than 40 and older than 80 years of age
• Resting Blood Pressure below 120/80 or above 159/99
• Smoker
• Physically active
• BMI below 25 kg/m2 or above 39.9 kg/m2
• Diagnosed with stroke for less than 4 months
• Diagnosed with any other cardiovascular diseases besides stroke and stage-1 hypertension

Where it is running

• Florida State University — Tallahassee, Florida, United States

Full record on ClinicalTrials.gov

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