Environments as Smoking Cues: Imaging Brain Substrates, Developing New Treatments (CameraCue)

Completed · Not applicable

Conditions studied: Smoking, Healthy

In brief

The overarching goals of this proposal are to 1) identify the network of brain regions specifically activated by personal smoking environment cues and 2) to evaluate the effects of exposure to these cues on smoke self-administration and subjective reactivity. The results of this study will inform the development of novel and more efficacious cue-exposures therapies targeted at helping smokers quit smoking and will provide novel mechanism information regarding the influence of environmental context on drug taking. The investigator hypothesizes that cue-exposure treatments (CETs), in which drug use is prevented during exposure to drug cues (e.g. lit cigarette) have been of limited efficacy in part because they have not included cues representative of the contexts in which drug use occurs. By demonstrating that context cues have a differential and robust influence on brain and behavioral responses, we will have provided a substantial basis for including such stimuli in the context of treatment. At the same time, we will have identified novel mechanisms by which such stimuli promote continued drug use and relapse.

Key facts

Study ID

NCT01840111

Run by

Duke University

People needed

67

Starts

2012-12-01

Expected to finish

2014-07-01

Last updated by the study team

2017-01-31

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• generally healthy
• between the ages of 18 and 55
• smoking an average of 5 cigarettes per day for at least one year
• breath CO (carbon monoxide) level > 8 ppm (if ≤ 8 ppm, then NicAlert Strip > 2)
• no interest in quitting smoking for the duration of time required for the experiment
• right-handed as measured by a three-item scale used in our laboratory
• ability to identify 4 personal smoking and 4 personal non-smoking places

You may not qualify if…

• inability to attend all required experimental sessions
• significant health problems
• use of psychoactive medications
• use of smokeless tobacco
• current alcohol or drug abuse
• use of illegal drugs as measured by urine drug screen
• current use of nicotine replacement therapy or other smoking cessation treatment
• presence of conditions that would make MRI unsafe (e.g., pacemaker)

Where it is running

• Duke University Medical Center — Durham, North Carolina, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.