Assessment of the Safety, Tolerability and Efficacy of MEDI8968 in Subjects With Moderate to Severe Hidradenitis Suppurativa

Stopped early · Phase 2 · Has a placebo group

Conditions studied: Hidradenitis Suppurativa

In brief

The purpose of this study is to gain initial evidence for the safety, tolerability and efficacy of MEDI8968 for the treatment of subjects with moderate to severe hidradenitis suppurativa

Key facts

Study ID

NCT01838499

Run by

AstraZeneca

People needed

224

Starts

2013-05-01

Expected to finish

2014-10-01

Last updated by the study team

2016-09-01

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Hidradenitis suppurativa (HS) (moderate to severe)
• Diagnosis of HS for at least 1 year
• At least 5 active inflammatory lesions in at least 2 locations
• On a stable dose of antibiotics and/or analgesics for at least 4 weeks (if already taking these medications)
• Average pain score of 3-9.

You may not qualify if…

• History of cyclic neutropenia
• Laboratory assessment abnormalities
• Underlying disorder considered unsuitable for inclusion
• Other skin diseases that may interfere with HS assessment
• Pregnancy or planning for pregnancy

Where it is running

• Research Site — Phoenix, Arizona, United States
• Research Site — Bakersfield, California, United States
• Research Site — Fremont, California, United States
• Research Site — Los Angeles, California, United States
• Research Site — San Diego, California, United States
• Research Site — San Francisco, California, United States
• Research Site — Miami, Florida, United States
• Research Site — Orange Park, Florida, United States
• Research Site — Ormond Beach, Florida, United States
• Research Site — Tampa, Florida, United States
• Research Site — Atlanta, Georgia, United States
• Research Site — Macon, Georgia, United States
• Research Site — Skokie, Illinois, United States
• Research Site — West Dundee, Illinois, United States
• Research Site — Evansville, Indiana, United States
• Research Site — Indianapolis, Indiana, United States
• Research Site — Rockville, Maryland, United States
• Research Site — St Louis, Missouri, United States
• Research Site — Forest Hills, New York, United States
• Research Site — Chapel Hill, North Carolina, United States
• Research Site — High Point, North Carolina, United States
• Research Site — Winston-Salem, North Carolina, United States
• Research Site — Hershey, Pennsylvania, United States
• Research Site — Philadelphia, Pennsylvania, United States
• Research Site — Rapid City, South Dakota, United States

Full record on ClinicalTrials.gov

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