Biochemical and Electrocardiographic Signatures in the Detection of Exercise-induced Myocardial Ischemia

Recruiting now

Conditions studied: Coronary Artery Disease, Angina, Stable, Exercise Test, Biological Markers, SPECT

In brief

The primary aim is to perform the largest study worldwide to evaluate novel biochemical and electrocardiographic signatures alone as well as in combination with the standard 12-lead exercise ECG in the detection of exercise-induced myocardial ischemia (diagnostic endpoint). The secondary aim is to evaluate these innovative tools in the risk prediction for the occurrence of cardiovascular death and acute myocardial infarction during long-term follow-up.

Key facts

Study ID

NCT01838148

Run by

University Hospital, Basel, Switzerland

People needed

4000

Starts

2004-05-01

Expected to finish

2025-12-01

Last updated by the study team

2025-07-11

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients presenting with suspected exercise-induced myocardial ischemia referred for rest/ergometry myocardial perfusion SPECT

You may not qualify if…

• Age < 18 years
• Pregnancy
• Unable or unwilling to give informed consent
• Symptoms at rest or minor exertion

Where it is running

• University Hospital Basel — Basel, Switzerland (enrolling)

Full record on ClinicalTrials.gov

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