Brain Perfusion in Pantothenate Kinase-associated Neurodegeneration (PKAN)

Completed

Conditions studied: Pantothenate Kinase-associated Neurodegeneration (PKAN)

In brief

The purpose of this study is to learn whether blood flow in the brain is normal in people with pantothenate kinase-associated neurodegeneration (PKAN). Specifically, preliminary data suggest a region of the brain called the globus pallidus (GP), a key region affected by PKAN, may have reduced blood flow. Standard MRI and perfusion scanning techniques will be used to learn about cerebral blood flow in the globus pallidus and compare it to blood flow in other brain regions as well as to healthy controls.

Key facts

Study ID

NCT01838018

Run by

Susan J. Hayflick

People needed

10

Starts

2013-04-01

Expected to finish

2018-01-01

Last updated by the study team

2018-05-29

Who can join

Age: 7 and older, up to 75. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• diagnosis of PKAN confirmed by MRI and gene testing
• able to undergo MRI for approximately 1 hour without sedation

You may not qualify if…

• deep brain stimulators or other conditions that warrant avoidance of a strong magnetic field
• previous reaction to gadolinium (Gd) contrast agent
• acute or chronic kidney dysfunction
• pregnant and/or nursing at time of study

Where it is running

• Oregon Health & Science University — Portland, Oregon, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.