Monitoring of Neoadjuvant Therapy in Locally-Advanced Breast Cancer
Stopped early
Conditions studied: Locally Advanced Breast Cancer
In brief
The purpose of this study is to determine whether four new alternative imaging methods can be used to follow the response of breast cancer to the treatment patients are being given. These methods produce an image of the inside of the breast so that doctors can better decide whether breast cancer is responding to therapy. An important part of the study is to examine the same person with all methods in order to directly compare results. The four methods are: MRI Elasticity Imaging (abbreviated MRE), Electrical Impedance Spectroscopy (abbreviated EIS), Microwave Imaging and Spectroscopy (abbreviated MIS), Near Infrared Spectroscopy (abbreviated NIR). In addition to the experimental imaging methods, patients may also undergo a contrast-enhanced MRI, and/or additional mammography, which will help researchers compare the experimental methods. These additional examinations are accepted diagnostic procedures; they are not experimental. Some participants will have one or both of these additional examinations if clinically indicated.
Key facts
- Study ID
- NCT01837563
- Run by
- Dartmouth-Hitchcock Medical Center
- People needed
- 36
- Starts
- 2006-09-01
- Expected to finish
- 2015-09-01
- Last updated by the study team
- 2015-09-30
Who can join
Age: 18 and older. Sex: female. Healthy volunteers: not accepted.
You may qualify if…
- Locally advanced breast cancer, with or without metastatic disease
- Patient to receive systemic therapy
- Breast size and epithelial integrity adequate to allow alternate imaging exams.
- Patient able to provide written informed consent.
- No serious associated psychiatric illness
- Age ≥ 18 years old
You may not qualify if…
- Cardiac pacemaker
- Any implanted electronic device
- Severe claustrophobia
- Allergy to the MRI contrast agent gadolinium
Where it is running
- Dartmouth-Hitchcock Medical Center — Lebanon, New Hampshire, United States
Full record on ClinicalTrials.gov
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