Regular Swimming, Vascular Function, and Arthritis
Completed · Not applicable
Conditions studied: Osteoarthritis
In brief
Hypothesis #1: The investigators hypothesize that both swimming training and cycling training will demonstrate significant improvements in endothelium-mediated vasodilation and central artery compliance in this population and that there will be no difference in the magnitude of increases between the water-based and land-based exercise interventions. Hypothesis #2: The investigators hypothesize that the improvements in endothelium-dependent vasodilation and arterial compliance in response to exercise training interventions will be related to the corresponding reductions in inflammatory biomarkers. Hypothesis #3: The investigators hypothesize that both swimming exercise and cycling exercise will improve functional capacities and disease progression in middle-aged and older adults with osteoarthritis.
Key facts
- Study ID
- NCT01836380
- Run by
- University of Texas at Austin
- People needed
- 48
- Starts
- 2013-01-01
- Expected to finish
- 2014-12-01
- Last updated by the study team
- 2015-03-26
Who can join
Age: 40 and older, up to 90. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- All the subjects will have a radiological diagnosis of osteoarthritis according to American College of Rheumatology criteria
- Subjects will be sedentary (i.e., no regular physical activity for at least the prior 1 year)
You may not qualify if…
- Subjects with significant intima thickening,
- plaque formation, and/or characteristics of atherosclerosis.
- unstable cardiac or pulmonary diseases.
- joint replacement surgery in the previous year.
- intraarticular injection nor systemic steroids within previous 3 months.
- severe disabling co-morbidity that disallows receiving exercise therapy.
- excess alcohol use (>21 drinks/week).
- unwillingness to perform exercise.
- fear of water.
- mental incapability
Where it is running
- The University of Texas at Austin — Austin, Texas, United States
Full record on ClinicalTrials.gov
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