Neuroprotective Effects of Remote Ischemic Preconditioning (RIPC) During Infant Cardiac Surgery

Completed · Not applicable · Has a placebo group

Conditions studied: Heart Defects, Congenital

In brief

The purpose of this study is to look at whether the use of a simple technique before surgery, which involves inflating a blood pressure cuff on the infant's leg, can improve development of language, motor and thinking skills at 12 months of age. Some research has found that a brief shortage of blood supply to an organ (such as a leg) at level that does not cause harm may help the body to tolerate a longer and more severe shortage of blood (for example, during surgery).

Key facts

Study ID

NCT01835392

Run by

Nemours Children's Clinic

People needed

137

Starts

2011-09-01

Expected to finish

2018-01-01

Last updated by the study team

2020-03-16

Who can join

Age: 0 and older, up to 1. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Infants <7 months of age
• Undergoing open heart surgery
• Written informed consent

You may not qualify if…

• Presence of known gross neurologic abnormality preoperatively
• History of birth asphyxia
• Non-English speaking family

Where it is running

• Nemours Cardiac Center — Wilmington, Delaware, United States

Full record on ClinicalTrials.gov

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