Correlates and Consequences of Increased Immune Activation in Injection Drug Users

Completed

Conditions studied: Intravenous Drug Usage

In brief

The goal of this study is to learn how injection drug use may affect the immune system.

Key facts

Study ID

NCT01831284

Run by

Rockefeller University

People needed

201

Starts

2012-12-01

Expected to finish

2014-09-01

Last updated by the study team

2014-11-06

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Ability to give informed consent
• Between the ages of 18 and 55
• Absence of medical conditions that would preclude flexible sigmoidoscopy
• Absence of active opportunistic infection requiring active therapy including antibiotics or anti-neoplastics (note this does not include prophylactic antibiotic therapy)

You may not qualify if…

• History of bleeding disorder
• Platelet count below 70,000
• INR>1.5 or PTT>2X control
• Active use of anticoagulants or aspirin therapy that cannot be interrupted
• Comorbid diagnosis of inflammatory bowel disease
• Pregnancy, incarceration, mentally disabled individuals
• HIV-1 infection
• Currently on Hepatitis C treatment

Where it is running

• The Rockfeller University — New York, New York, United States

Full record on ClinicalTrials.gov

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