Advanced MR Imaging for Early Biologic Tumor Changes to Neoadjuvant Chemoradiation Treatment for Rectal Cancer

Completed · Not applicable

Conditions studied: Rectal Cancer

In brief

The purpose of this study is to see whether three new types of MRI techniques used during magnetic resonance imaging (MRI) of the pelvis to look at rectal cancer can help doctors to tell if the tumor is getting better in response to the radiation and/or chemotherapy treatments.

Key facts

Study ID

NCT01830582

Run by

Memorial Sloan Kettering Cancer Center

People needed

28

Starts

2013-04-09

Expected to finish

2017-06-20

Last updated by the study team

2017-06-22

Who can join

Age: 21 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with primary locally advanced rectal adenocarcinoma (0-18cm from the anal verge) confirmed by MSKCC pathologist and eligible to undergo chemoradiation and surgical resection at MSKCC.
• Written informed consent
• Age equal to or greater than 21 years
• Willing and able to undergo all study procedures
• Patients must have a planned surgical resection of the rectum

You may not qualify if…

• Patients younger than 21 years
• Pregnant and nursing women
• Contraindications for MRI (such as claustrophobia, pacemaker, non MR-compatible artificial heart valves, cochlear implants, surgical clips in the brain, metal fragments in eye)
• Estimated GFR (using Cockcroft formula Appendix 2) less than 30 ml/min/1.73m2 (FDA advises caution in using gadolinium-based contrast agents in patients with severe renal impairment).
• History of allergic reaction to MR contrast media
• Inability to give informed consent in person

Where it is running

• Memorial Sloan Kettering Cancer Center — New York, New York, United States

Full record on ClinicalTrials.gov

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