Atherosclerotic Coronary Vulnerable Plaque: Correlation With Coronary Artery Calcium
Withdrawn before enrolling · Not applicable
Conditions studied: Coronary Artery Disease
In brief
The aim of this study is to compare the relationship between the coronary artery calcification assessed by MDCT with the plaque characteristics and necrotic lipid core content of non-intervened coronary segments assessed with near infrared spectroscopy (NIRS) in patients with symptomatic coronary artery disease (CAD).
Key facts
- Study ID
- NCT01830062
- Run by
- Medstar Health Research Institute
- People needed
- 0
- Starts
- 2013-11-01
- Expected to finish
- 2021-06-01
- Last updated by the study team
- 2021-07-02
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patient is ≥18 years of age
- Patient is clinically indicated due to angina, abnormal functional test or other ischemic symptoms to undergo non-emergent cardiac catheterization with IVUS evaluation i.If the patient has not had a cardiac MDCT with CACS meeting the protocol requirements within 3 months prior to the cardiac catheterization, the patient is able to undergo CACS following LipiScan IVUS and NIRS evaluation, prior to any coronary revascularization ii. If the patient has had a cardiac MDCT evaluation with CACS meeting the protocol requirements within 3 months prior to the cardiac catheterization, LipiScan IVUS and NIRS imaging will be completed in at least two (2) major epicardial vessels prior to any coronary revascularization
- At least two (2) major epicardial native vessels are suitable for interrogation by LipiScan IVUS imaging and NIRS evaluation, defined as:
- i.At least 30 mm of vessel that is > 2.0mm in diameter ii.No other contraindications to imaging
- No contraindications for LipiScan IVUS and NIRS evaluation
- No contraindications for CACS evaluation by MDCT
- Subject must be able to provide informed consent form and comply with the protocol requirements
You may not qualify if…
- Evidence of clinical hemodynamic instability in the 6 hours before either procedure
- Prior history of percutaneous coronary intervention (PCI) with stent placement
- Prior history of bypass grafts
- Female subject that is pregnant or lactating
- Any other factor that the investigator feels would put the patient at increased risk or otherwise make the patient unsuitable for participation in the protocol
Where it is running
- MedStar Washington Hospital Center — Washington D.C., District of Columbia, United States
Full record on ClinicalTrials.gov
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