Investigating the Efficacy of a Dentifrice in Providing Long Term Relief From Dentinal Hypersensitivity

Completed · Phase 3

Conditions studied: Dentine Hypersensitivity

In brief

Clinical studies have demonstrated long term relief from dentine hypersensitivity with twice daily brushing of a toothpaste containing stannous fluoride in comparison to marketed (negative) controls. The aim of this study is to evaluate the effectiveness of a stannous fluoride dentifrice in the treatment of dentinal hypersensitivity compared to a marketed (negative) control, over a period of 56 days (8 weeks) with twice daily brushing.

Key facts

Study ID

NCT01827670

Run by

GlaxoSmithKline

People needed

119

Starts

2013-02-01

Expected to finish

2013-05-01

Last updated by the study team

2015-01-26

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Participants with self-reported history of dentinal hypersensitivity lasting more than 6 months but not more than 10 years.
• Participants with minimum of 20 natural teeth.
• At screening, a minimum of two accessible teeth (incisors, canines, premolars) that meet all of the following criteria.
• Teeth showing signs of facial/cervical gingival recession and/or signs of erosion or abrasion.
• Teeth with Gingival Index score ≤1 and a clinical mobility of ≤1.
• Teeth that are determined to be sensitive by the subject following a 1 second air blast to the cervical margin.

You may not qualify if…

• Presence of chronic debilitating disease which, in the opinion of the investigator, could affect study outcomes.
• Any condition which, in the opinion of the investigator, causes dry mouth.
• Tooth with evidence of current or recent caries, or reported treatment of decay in 12 months of screening.
• Participant using of a desensitising dentifrice within 6 weeks of screening

Where it is running

• Salus Research, Inc. — Fort Wayne, Indiana, United States

Full record on ClinicalTrials.gov

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