PET Imaging Study Using [11C]PIB in Subjects With AD & Healthy Volunteers

Completed · Phase 1

Conditions studied: Alzheimer's Disease

In brief

The purpose of this study is to investigate the radiotracer \[11C\] PIB in participants with probably Alzheimer's Disease (AD) and healthy age-matched controls.

Key facts

Study ID

NCT01826110

Run by

Johns Hopkins University

People needed

21

Starts

2013-09-01

Expected to finish

2018-07-01

Last updated by the study team

2019-03-05

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Male or female subjects at least 18 years of age
• Subjects who in the opinion of the investigator based on medical history and physical exam can tolerate the PET scan procedures

You may not qualify if…

• Have clinically significant hepatic, renal, pulmonary, metabolic, or endocrine disturbances
• Have current clinically significant cardiovascular disease.
• Have a history of drug or alcohol abuse within the last year, or prior prolonged history of abuse
• Have a clinically significant infectious disease, including Acquired Immune Deficiency Syndrome (AIDS) or Human Immunodeficiency Virus (HIV) infection or previous positive test for hepatitis
• Women of childbearing potential must not be pregnant (negative urine beta-hCG at the time of screening and negative urine beta-hCG on the day of imaging) or lactating at screening or at day of imaging
• Have a history of relevant severe drug allergy or hypersensitivity (Relevant severe drug allergies should be determined by the PI, and any questions about a subject's eligibility can be directed to Avid. If a subject has a history of severe drug allergies, it may be dangerous for them to participate in a study with a novel compound
• Have received an investigational medication within the last 30 days. Current clinically significant or unstable medical comorbidities, as indicated by history or physical exam
• Have received a radiopharmaceutical for imaging or therapy within the past 7 days prior to the imaging session for this study
• Body weight > 300 pounds
• History of significant radiation exposure
• Participants with pacemakers, implanted electronic hearing devices, aneurysm clips, shrapnel, unallowed prosthetic or other metallic device in their bodies
• Pre-existing CNS disease (other than dementia), endocrine, or severe cardiovascular disease (MI, CABG, angioplasty)

Where it is running

• Johns Hopkins Medical Institution- Dept of Radiology , Division of Nuclear Medicine — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

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