A Study of Evacetrapib (LY2484595) in Participants With Severe Renal Impairment and in Healthy Participants
Completed · Phase 1
Conditions studied: Cardiovascular Disease
In brief
The purpose of this study is to measure how much of the study drug, evacetrapib, enters the blood stream and how long it takes the body to dispose of the study drug when given to participants with severe renal (kidney) impairment compared to participants with normal renal (kidney) function. This study will last approximately 8 weeks.
Key facts
- Study ID
- NCT01825889
- Run by
- Eli Lilly and Company
- People needed
- 20
- Starts
- 2013-04-01
- Expected to finish
- 2013-10-01
- Last updated by the study team
- 2018-10-09
Who can join
Age: 18 and older, up to 85. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Female participants are not of child-bearing potential
- Have a body mass index of 18 to 40 kilograms per square meter (kg/m\^2)
- Participants with normal renal function - healthy as determined by medical history, physical examination, and other screening procedures, with normal renal function (assessed by estimated creatinine clearance [CLcr] greater than or equal to 90 milliliters per minute [mL/min] at screening)
- Participants with severe renal impairment - estimated CLcr less than 30 mL/min at screening and are not undergoing hemodialysis
You may not qualify if…
- Have a history or presence of cardiovascular, respiratory, hepatic, renal, gastrointestinal, endocrine, hematological, or neurological disorders capable of significantly altering the absorption, metabolism, or elimination of drugs; of constituting a risk when taking the study medication; or of interfering with the interpretation of data
- Participants who are unwilling to comply with the dietary requirements/restrictions during the study
- Hemoglobin less than 9 grams/deciliter (g/dL) or significant active hematological disease from causes other than underlying renal disease
Where it is running
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. — Miami, Florida, United States
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. — Orlando, Florida, United States
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. — Saint Paul, Minnesota, United States
Full record on ClinicalTrials.gov
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