Study of Using Long Acting Antihistamine to Treat Opioid Induced Itching

Stopped early · Phase 4 · Has a placebo group

Conditions studied: Pruritus

In brief

The purpose of this study is determine if long acting antihistamine like cetirizine can help with itching induced by opioid pain medications.

Key facts

Study ID

NCT01825655

Run by

Virginia Commonwealth University

People needed

3

Starts

2014-09-01

Expected to finish

2017-11-01

Last updated by the study team

2018-10-10

Who can join

Age: 6 and older, up to 18. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Children age 6-18yrs on opioids who develop pruritus and are willing to participate in the study

You may not qualify if…

• Children with history of chronic urticaria
• Children with other chronic pruritic condition like eczema, contact dermatitis, psoriasis
• Children with known hypersensitivity to cetirizine/zyrtec
• Children on H1 antihistamine like diphenhydramine, hydroxyzine, cetirizine, loratadine, fexofenadine, chlorpheniramine within the last 7days prior to randomization
• Children who have received Ondansetron within 24hrs prior to randomization
• Children who are on Tricyclic antidepressants
• Children who are unwilling or unable to swallow the capsule.
• Children with chronic liver or kidney disease

Where it is running

• Children's Hospital of Richmond at VCU — Richmond, Virginia, United States

Full record on ClinicalTrials.gov

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