Temozolomide With or Without Capecitabine in Treating Patients With Advanced Pancreatic Neuroendocrine Tumors

Running, not enrolling · Phase 2

Conditions studied: Gastrinoma, Glucagonoma, Insulinoma, Islet Cell Carcinoma, Pancreatic Polypeptide Tumor, Recurrent Islet Cell Carcinoma, Somatostatinoma

In brief

This randomized phase II trial studies how well giving temozolomide with or without capecitabine works in treating patients with advanced pancreatic neuroendocrine tumors. Drugs used in chemotherapy, such as temozolomide and capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known whether temozolomide is more effective with or without capecitabine in treating patients with advanced pancreatic neuroendocrine tumors.

Key facts

Study ID

NCT01824875

Run by

ECOG-ACRIN Cancer Research Group

People needed

144

Starts

2013-08-08

Expected to finish

2026-12-01

Last updated by the study team

2026-02-25

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patient must have histologically or pathologically confirmed locally unresectable or metastatic low or intermediate grade pancreatic neuroendocrine tumor
• Patient must have measurable disease by Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 criteria; baseline measurements and evaluations of all sites of disease must be obtained <= 4 weeks prior to randomization and must be acquired by multiphasic CT or contrast magnetic resonance imaging (MRI)
• Date of last documented disease progression must be within 12 months from date of randomization
• Prior everolimus and/or sunitinib therapy is allowed, so long as it was discontinued >= 4 weeks prior to randomization
• Concurrent somatostatin analogues are allowed provided that patients
• Have been on a stable dose for 8 weeks and
• Have documented disease progression on that dose
• Chemoembolization is allowed if ≥ 4 weeks from study entry. There are 2 possible scenarios:
• If patient has hepatic disease only: they need to have progressed in the liver since chemoembolization and have measurable disease by RECIST 1.1 in order to be eligible.
• If patient has hepatic and extrahepatic disease: they will need to have progressed inside OR outside the liver and have measureable disease by RECIST 1.1 in order to be eligible.
• Leukocytes >= 3,000/mm\^3
• Absolute neutrophil count >= 1,500/mm\^3
• Hemoglobin >= 9 g/dL
• Platelets >= 100,000/mm\^3
• Total bilirubin <= institutional upper limit of normal (ULN) or <= 1.5 X institutional ULN (if the patient has liver metastases)
• Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase [SGOT])/alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT]) <= 3 X institutional ULN or (<= 5 X institutional ULN if the patient has liver metastases)
• Serum creatinine <= 1.5 X institutional ULN
• Patient must have Eastern Cooperative Oncology Group (ECOG) performance status 0-1
• Patient must have life expectancy >= 12 weeks all females of childbearing potential must have a blood test or urine study within =< 2 weeks prior to randomization to rule out pregnancy; a female of childbearing potential is any woman, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria:
• Has not undergone a hysterectomy or bilateral oophorectomy; or
• Has not been naturally postmenopausal for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)
• Women of childbearing potential and sexually active males must be strongly advised to use an accepted and effective method of contraception or to abstain from sexual intercourse for the duration of their participation in the study; should a woman become pregnant while participating in this study, she should inform her treating physician immediately; if a man impregnates a woman while participating in this study, he should inform his treating physician immediately
• Patient must be able to swallow pills
• Patient must be able to tolerate CT or magnetic resonance (MR) imaging including contrast agents as required for their treatment and the protocol

You may not qualify if…

• Small cell carcinoma
• Prior temozolomide, dacarbazine (DTIC), or capecitabine, or 5-FU (fluorouracil) therapy
• Receiving any other investigational agents while on study treatment
• Receiving Coumadin while on treatment; other anticoagulants are allowed
• Patients with either clinically apparent central nervous system metastases or carcinomatous meningitis are ineligible
• Active or uncontrolled infection or serious medical or psychiatric illness
• History of allergic reactions attributed to compounds of similar chemical or biologic composition to temozolomide or capecitabine
• Absorption issues that would limit the ability to absorb study agents
• Patients with a history of the following within 12 months of study entry:
• Arterial thromboembolic events
• Unstable angina
• Myocardial Infarction
• Symptomatic peripheral vascular disease
• Patients with previous or concurrent malignancy; exceptions are made for patients who meet any of the following conditions:
• Non-melanoma skin cancer, in situ cervical cancer, or breast cancer in situ OR
• Prior malignancy completely excised or removed and patient has been continuously disease free for > 5 years OR
• Prior malignancy cured by non-surgical modalities and patient has been continuously disease free for > 5 years
• Pregnant or breast-feeding

Where it is running

• Kaiser Permanente-Deer Valley Medical Center — Antioch, California, United States
• Kaiser Permanente Medical Group - Baldwin Park — Baldwin Park, California, United States
• Kaiser Foundation Hospital — Bellflower, California, United States
• Alta Bates Summit Medical Center-Herrick Campus — Berkeley, California, United States
• Mills - Peninsula Hospitals — Burlingame, California, United States
• Kaiser Permanente Hospital — Fontana, California, United States
• Kaiser Permanente, Fremont — Fremont, California, United States
• Kaiser Permanente — Fresno, California, United States
• Kaiser Permanente - Harbor City — Harbor City, California, United States
• Kaiser Permanente, Hayward — Hayward, California, United States
• Southern California Permanente Medical Group — Irvine, California, United States
• Kaiser Permanente Los Angeles Medical Center — Los Angeles, California, United States
• University of Southern California/Norris Cancer Center — Los Angeles, California, United States
• Kaiser Permanente-West Los Angeles — Los Angeles, California, United States
• Cedars-Sinai Medical Center — Los Angeles, California, United States
• Kaiser Permanente-Modesto — Modesto, California, United States
• Sutter Cancer Research Consortium — Novato, California, United States
• Kaiser Permanente-Oakland — Oakland, California, United States
• University of California Medical Center At Irvine-Orange Campus — Orange, California, United States
• Kaiser Permanente - Panorama City — Panorama City, California, United States
• Kaiser Permanente-Redwood City — Redwood City, California, United States
• Kaiser Permanente-Richmond — Richmond, California, United States
• Kaiser Permanente Medical Center — Riverside, California, United States
• Kaiser Permanente-Roseville — Roseville, California, United States
• Kaiser Anaheim Medical Center — Anaheim, California, United States

Full record on ClinicalTrials.gov

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