Effects of Quitting Study A Test of Pre-clinical Findings
Completed · Not applicable
Conditions studied: Smoking
In brief
The most widely-accepted animal model of nicotine withdrawal states stopping nicotine makes rewarding events become less rewarding. The current study will test if this is true in humans. If we find tobacco abstinence does make rewards less rewarding, this would suggest new symptoms to add to official descriptions of nicotine withdrawal. It would also suggest we need to develop new behavioral and pharmacological interventions to correct this problem. If stopping smoking does not make rewards less rewarding, this would suggest this animal model does not apply to the human condition and we need to continue to search for an animal model of tobacco withdrawal that is relevant to smokers stopping smoking.
Key facts
- Study ID
- NCT01824511
- Run by
- University of Vermont
- People needed
- 287
- Starts
- 2013-04-01
- Expected to finish
- 2015-09-01
- Last updated by the study team
- 2016-03-14
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- For all participants:
- 18 yrs old or older
- able to read and understand verbal English fluently
- citizen or resident alien
- agree to abstain from illegal drugs during the study
- For current smokers:
- currently smoke >10 cigarettes daily for > 1 yr
- want to quit smoking for good via abrupt cessation without treatment
- willing to quit 7-14 days from study entry and not reduce before quitting
- no reduction in cigs/day by >25% in the last month
- agree to no use of non-cigarette tobacco, non-tobacco nicotine, marijuana, illegal drugs, electronic cigarettes, or smoking cessation medications during the study
- have carbon monoxide (CO) level > or = 8 ppm at the time of consent
- no current use of prescribed psychoactive medications, including smoking cessation products.
- For former smokers:
- smoked >10 cigarettes daily for > 1 yr
- quit at least 1 yr ago
- use of cigarettes or e-cigarettes 5 or fewer times in past year
- no tobacco or nicotine-containing product in last month
- agree to no use of non-cigarette tobacco, non-tobacco nicotine, marijuana, illegal drugs, electronic cigarettes, or smoking cessation medications during the study
- have carbon monoxide (CO) level < 8 ppm at the time of consent
- no current use of prescribed psychoactive medications, including smoking cessation products.
- Exclusion Criteria for all participants:
- History of hand or wrist problems that could be exacerbated by study participation or interferes with completion of tasks
- current (last year) mood or alcohol/drug-related psychiatric disorder or any neurological condition that could influence reward sensitivity; e.g. Parkinsonism
- used marijuana 2 or more times in the last month
Where it is running
- Dartmouth College — Hanover, New Hampshire, United States
- University of Vermont — Burlington, Vermont, United States
Full record on ClinicalTrials.gov
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