Genetic Risks for Bicuspid Aortic Valve Disease

Completed

Conditions studied: Bicuspid Aortic Valve, Unicuspid Aortic Valve

In brief

Bicuspid Aortic Valve (BAV) is the most common congenital heart malformation in adults, but very little is known about the genetic causes or risk factors for adverse outcomes. Currently, it is estimated that most cases of aortic stenosis in patients less than 65 years old are caused by BAVs. BAV patients are also at high risk to develop aneurysms of the ascending aorta, which may lead to aortic dissections. Dr. Prakash and his colleagues plan to use individual genetic information to identify persons with BAV who are at high risk for complications and to customize therapies.

Key facts

Study ID

NCT01823432

Run by

The University of Texas Health Science Center, Houston

People needed

454

Starts

2012-03-01

Expected to finish

2022-09-19

Last updated by the study team

2022-09-21

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• At least 18 years of age
• Diagnosis of bicuspid or unicuspid aortic valve

You may not qualify if…

• Less than 18 years of age
• Recognized syndrome or identified genetic mutation

Where it is running

• University of Texas Health Science Center Houston — Houston, Texas, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.