Chlorthalidone Compared to Hydrochlorothiazide on Endothelial Function

Withdrawn before enrolling · Phase 4 · Has a placebo group

Conditions studied: Hypertension

In brief

Chlorthalidone will result in improved endothelial function compared to hydrochlorothiazide as measured by flow mediated vasodilatation.

Key facts

Study ID

NCT01822860

Run by

Creighton University

People needed

0

Starts

2013-03-01

Expected to finish

2015-02-01

Last updated by the study team

2015-03-25

Who can join

Age: 19 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 19 or older
• Diagnosis of hypertension
• Current blood pressure > 120/80 mm Hg

You may not qualify if…

• Use of a thiazide-type diuretic within the last 1 month
• Known allergy to any study medications
• History of gout or hyperuricemia
• SCr >/= 1.8 mg/dl or CrCl < 25 ml/min
• Pregnancy or breastfeeding or planning to become pregnant during study period
• Dementia or cognitive impairment
• Hypokalemia
• Acute coronary syndrome or stroke within 6 months
• Current use of sildenafil, tadalafil, or vardenafil

Where it is running

• Creighton University — Omaha, Nebraska, United States

Full record on ClinicalTrials.gov

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