Pain Control After Cardiac Surgery Using Intravenous Acetaminophen

Completed · Not applicable · Has a placebo group

Conditions studied: Pain

In brief

Evaluate the efficacy of IV acetaminophen; compared to a placebo, in reducing opioid consumption and/or pain intensity scores after cardiac surgery.

Key facts

Study ID

NCT01822821

Run by

The Cleveland Clinic

People needed

150

Starts

2013-03-01

Expected to finish

2015-03-01

Last updated by the study team

2017-05-15

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• - Males or females 18 years of age or older.
• Non-emergency cardiac surgery via a midline sternotomy at Cleveland Clinic Main Campus.

You may not qualify if…

• Redo cardiac surgery.
• Combined CABG (Coronary Artery Bypass Graft)\& valve replacement, multiple valve replacements, Ascending aortic or aortic arch surgery.
• Weight < 50 Kg or Body mass index > 38 kg/m2.
• Left ventricle EF ¡Ü 35% ,Right ventricular moderate or severe dysfunction.
• Severe (3-4 +) Tricuspid Regurgitation.
• Recent stroke (within 6 months).
• Severe lung disease requiring home O2 therapy.
• Preoperative renal insufficiency (Creatinine > 2.0) or on dialysis.
• History of liver cirrhosis or active liver disease.
• Chronic pain conditions controlled by preoperative opioid administration.
• Known allergy to acetaminophen or fentanyl.

Where it is running

• Cleveland Clinic — Cleveland, Ohio, United States

Full record on ClinicalTrials.gov

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