Brain Alterations and Cognitive Impairment in Older Adults With Heart Failure
Completed
Conditions studied: Heart Failure
In brief
Cognitive impairment, commonly reported as difficulty with memory and executive function, is a widely recognized clinical challenge for older persons with heart failure (HF). Little is known about the relationship between brain MRI and cognitive impairment in older persons with HF. A limited number of studies have investigated brain MRI in adults with HF and produced conflicting results. Previous findings are limited by use of lower resolution scanners (1.5 Tesla), lack of MRI techniques (i.e. combining structural sequences with perfusion sequences) and recruitment of mixed age samples. Based on these limitations, the purpose of this research plan is to explore the relationship between brain MRI and cognitive impairment in older persons with HF using high resolution structural and perfusion scans. To accomplish this goal, investigators will compare 40 adults with HF who are age \> 65 years old with 40 healthy, gender, age, and education matched controls. Investigators will obtain neuropsychological measures of multiple domains, as well as MRI measurements of the temporal lobe and prefrontal cortex at baseline and 12-months.
Key facts
- Study ID
- NCT01821638
- Run by
- University of Wisconsin, Madison
- People needed
- 40
- Starts
- 2013-04-01
- Expected to finish
- 2018-12-31
- Last updated by the study team
- 2019-02-06
Who can join
Age: 65 and older, up to 85. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- 65 years old or older
- English speaking and writing;
- Stable guideline based medication regimen for at least four weeks prior to enrollment
- New York Heart Association classification I-IV
You may not qualify if…
- Mini-Mental Status Exam score equal to or less than 24;
- Current diagnosis of neurological illnesses or movement disorders (e.g. Alzheimer's dementia, Parkinson's disease, Epilepsy);
- History of substance abuse/treatment;
- Untreated depression
- History of stroke;
- Hepatic insufficiency;
- Severe renal failure;
- Untreated anemia;
- Left ventricular assist device;
- History of the following within three months of study enrollment: acute myocardial infarction, unstable angina, coronary artery bypass surgery, percutaneous transluminal angioplasty, or biventricular pacemaker insertion;
- History of implantable device (or other MRI contraindications).
- Prisoners
- Pregnancy
Where it is running
- University of Wisconsin Hospital and Clinics — Madison, Wisconsin, United States
Full record on ClinicalTrials.gov
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