Milking the Umbilical Cord Versus Immediate Clamping in Pre-term Infants < 33 Weeks

Stopped early · Not applicable

Conditions studied: Prematurity

In brief

Anemia in preterm neonates is a significant problem encountered frequently in the neonatal intensive care unit. Most preterm neonates born at less than 33 weeks gestation will require at least one blood transfusion during their hospital course and many will require repeated transfusions. Blood transfusions, albeit necessary, carry increased risk of viral infections and transfusion reactions as well as increase the cost of healthcare. The umbilical cord and placenta harbor up to 40% of blood available during fetal life. The current standard of care is immediate umbilical cord clamping. The investigators are performing a randomized controlled trial comparing immediate cord clamping to milking the umbilical cord prior to clamping in neonate born preterm less than 33 weeks gestation. The investigators hypothesize that milking the umbilical cord will demonstrate the same benefits as delayed cord clamping, without delaying neonatal resuscitation.

Key facts

Study ID: NCT01819532
Run by: Johns Hopkins University
People needed: 22
Starts: 2011-09-01
Expected to finish: 2013-10-01
Last updated by the study team: 2017-12-11

Who can join

Age: 15 and older, up to 50. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

Preterm neonates delivered between 24 0/7 and 32 6/7
Mother carrying a fetus between 24-32 6/7 weeks estimated gestational age
Written parental consent

You may not qualify if…

Multiple gestation pregnancies (twins or higher order multiples)
Rh or other antibody sensitization
Hydrops fetalis
Known major congenital abnormality
Suspected abruptio placentae

Where it is running

Johns Hopkins Hospital — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

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