Ixabepilone and SBRT For Metastatic Breast Cancer

Withdrawn before enrolling · Phase 2

Conditions studied: METASTATIC BREAST CANCER

In brief

This study is being done to find the effect of Stereotactic body radiation therapy (SBRT) in combination with Ixabepilone for women with triple negative metastatic breast cancer.

Key facts

Study ID: NCT01818999
Run by: University of Texas Southwestern Medical Center
People needed: 0
Starts: 2013-08-01
Expected to finish: 2015-04-01
Last updated by the study team: 2020-08-20

Who can join

Age: 18 and older, up to 99. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

Biopsy proven triple negative invasive ductal or lobular metastatic breast cancer. Tumor estrogen, progesterone, and HER2 (tested by IHC or FISH) negative disease. (ER- defined as </=1% by IHC, PR- defined as </=1% by IHC, and HER2- by IHC 1+. If HER2 result by IHC is 2+ (equivocal), the tumor must be confirmed to be HER2- by FISH.
Age ≥ 18 years.
Patients must not have started Ixabepilone treatment more than 5 weeks prior to initiation of SBRT treatment.
Patients can have up to 6 sites of active extracranial disease(</=3 in the liver = one site and </=3 in the lung= one site) identified by CT scan, or PET/CT, within 8 weeks prior to initiation of SBRT (up to 2 contiguous vertebral metastasis will be considered a single site of disease). Maximum number of lesions treated is deemed as feasible per the treating radiation oncologist; ie: A patient with 4 right axillary lymph nodes, L1-L2 bone metastasis, 3 lung lesions, 1 left lung lesion, 2 liver lesions, and T2-T3 bone metastasis would be defined as having 6 sites of disease. Criteria to define a lesion in any location as a metastasis requiring local treatment as one of the sites for SBRT is any lesion clinically felt to be viable; defined as enlarging on CT/MRI or having persistent FDG avidity (Either SUV>3 or increase of SUV>20% over a 6 month interval).
Patients with skin nodules, skin invasion, or skin ulceration are eligible, if treatment with conventional radiation (at discretion of radiation oncologist) or surgery is planned. SBRT to skin nodules is not advised because of risk of skin necrosis.
. Patients must have had failure of an anthracycline, a taxane and capecitabine as per FDA approved criteria.
Performance status of ECOG 0,1, or 2.
Adequate organ and marrow function as defined below:
leukocytes ≥ 3,000/mcL
absolute neutrophil count ≥ 1,500/mcL
platelets ≥ 100,000/mcl
total bilirubin within normal institutional limits
AST(SGOT)/ALT(SPGT) ≤ 2.5 X institutional upper limit of normal
creatinine within normal institutional limits
Women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry, for the duration of study participation, and for 90 days following completion of therapy. Should a woman become pregnant or suspect she is pregnant while participating in this study, she should inform her treating physician immediately.
1 A female of child-bearing potential is any woman (regardless of sexual orientation, having undergone a tubal ligation, or remaining celibate by choice) who meets the following criteria:
Has not undergone a hysterectomy or bilateral oophorectomy; or
Has not been naturally postmenopausal for at least 12 consecutive months (i.e., has had menses at any time in the preceding 12 consecutive months).
Patients who would be receiving SBRT for lung tumors who are known or must have a documented forced expiratory volume in 1 second (FEV1)>/=30%.
Must have a CT C/A/P, or PET/CT scan within 8 weeks of enrollment.
Ability to understand and the willingness to sign a written informed consent

You may not qualify if…

Patients may not be actively receiving any other investigational agents.
Patients with untreated brain metastasis (patients can have whole brain radiation or stereotactic radiation to brain prior to enrollment).
Patients with leptomeningeal disease.
History of allergic reactions attributed to compounds of similar chemical or biologic composition to Agent(s) used in study. Patients with a history of severe reactions to Cremephor EL or its derivatives (polyoxyethylated castor oil) are ineligible as Ixabepilone contraindicated in these patients
Because the tolerance dose of SBRT to the gastrointestinal tract is not established, patients with metastatic disease invading the esophagus, stomach, intestines, or mesenteric lymph nodes will not be eligible.
Patients with more than 6 discrete extra-cranial sites.
Treatment for other carcinomas within the last 5 years, except cured non-melanoma skin and treated in-situ cancers.
Patients must not be pregnant or nursing due to the potential for congenital abnormalities and the potential of this regimen to harm nursing infants.
Patients must not be on concomitant CYP3A4 inhibitors or inducers (see section 4.3).

Where it is running

University of Texas Southwestern — Dallas, Texas, United States

Full record on ClinicalTrials.gov

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