Epigenetic and Developmental Effects of In Utero Exposure to Environmental Toxicants
Completed
Conditions studied: Full Term Infants, Environmental Exposures, Adiposity
In brief
Metabolic diseases such as obesity and diabetes are modern day epidemics. Early life exposure to an adverse developmental environment, including environmental toxins, are linked to increased susceptibility to obesity, metabolic syndrome and type 2 diabetes. Although the mechanisms underlying the fetal origins of metabolic disease are poorly understood, strong evidence suggests that alterations in the epigenome play a critical role in this process. The central hypothesis of this proposal is that intrauterine exposure to benzo\[a\]pyrene leads to epigenetic changes which will have functional consequences and may be a marker for, or may contribute to, increased susceptibility to adverse outcomes in childhood including increased adiposity and the subsequent development of obesity, metabolic syndrome or diabetes. The goals of this proposal are to: 1) determine benzo\[a\]pyrene levels in umbilical cord blood of newborns, 2) determine whether benzo\[a\]pyrene exposure during pregnancy correlates with early onset of obesity and metabolic disease by examining the children at 12 and 24 months of age, 3) determine whether in utero benzo\[a\]pyrene exposure programs metabolic disease through alterations in DNA methylation and gene expression, and 4) determine the plasticity of the DNA methylation patterns in the same offspring at 12 months of age. The long-term goal of this project is to define biomarkers that identify neonates at "high-risk" for diminished attainment of full health potential, who can then be targeted for preventative measures.
Key facts
- Study ID
- NCT01815385
- Run by
- Montefiore Medical Center
- People needed
- 110
- Starts
- 2013-03-01
- Expected to finish
- 2020-03-28
- Last updated by the study team
- 2021-02-11
Who can join
Age: any, up to 0. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Infants whose mothers were followed by the Obstetric Department at MMC, and
- Deliver a single healthy live term infant
You may not qualify if…
- Multiple gestation,
- Maternal depression,
- History of maternal smoking in the 3rd trimester of pregnancy,
- Infants in extremis,
- Apgar score <7 at 5 min and umbilical artery pH ≤7.25,
- Chromosomal/congenital abnormalities,
- Congenital infections, and
- Inborn errors of metabolism
Where it is running
- Montefiore Medical Center - Jack D. Weiler Division — The Bronx, New York, United States
Full record on ClinicalTrials.gov
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