Role of Neutrophil Activation
Completed · Not applicable
Conditions studied: Patients Requiring Endotracheal Intubation
In brief
Patients will undergo placement of an endotracheal tube (ETT) as standard of care. Tracheal lavage will be conducted using 5 mL of sterile saline solution by a push/suction technique. Specimen samples obtained by wall suction will be collected at 2 time points following intubation. Blood samples will be obtained at 2 time points, simultaneous with the collection of the tracheal specimens.
Key facts
- Study ID
- NCT01815229
- Run by
- Washington University School of Medicine
- People needed
- 82
- Starts
- 2013-03-01
- Expected to finish
- 2017-07-01
- Last updated by the study team
- 2019-07-15
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Ages 18 to 65
- American Society of Anesthesiologists Physical Status Classification (ASA) I and II
- Required to have endotracheal intubation
- Scheduled for short admission (<23 hrs), or ambulatory orthopedic surgery (ankle, shoulder, or extremity surgery); general surgery (exploratory laparotomy, cholecystectomy, ventral or inguinal hernia repair); obstetric/gynecological surgery(total abdominal hysterectomy, bilateral salpingo-oophorectomy); urologic surgery (nephrectomy, prostatectomy), lumbar spine surgery( discectomy, one or two level lumbar fusion) procedures.
- Estimated duration of surgery 3 to 4 hours.
- Provide informed consent
You may not qualify if…
- Active pulmonary disease within 5 days prior to enrollment
- On immunosuppressive medications
- Previous tracheal surgery
- On azithromycin
- Diabetes
- Pregnancy
- Smoking history of less than 6 weeks prior to surgery
- Surgery or intubation within 5 days of surgery
- Planned surgical procedure involving neck or thoracic regions
- Active pulmonary disease
- Autoimmune disease (HIV, AIDS, Rheumatoid Arthritis
- Hepatitis
- Cancer
Where it is running
- Washington University School of Medicine — St Louis, Missouri, United States
Full record on ClinicalTrials.gov
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