Evaluation of Mitochondrial Dysfunction in Severe Burn and Trauma Patients

Status unconfirmed · Not applicable

Conditions studied: Burns, Trauma

In brief

The purpose of this project is to evaluate the level of mitochondrial dysfunction several patient populations: Burn, trauma, and control group of healthy volunteers. Study hypothesis: Increased plasma concentrations of a newly discovered inflammatory mediated, called mtDNA DAMPS associated with the occurrence of multi-organ dysfunction syndrome in severly injured patients. As the severity of a burn injury or trauma injury increase, so will systemic mitochondrial dysfunction.

Key facts

Study ID

NCT01812941

Run by

University of South Alabama

People needed

50

Starts

2011-09-01

Expected to finish

2021-12-01

Last updated by the study team

2021-05-28

Who can join

Age: 19 and older, up to 70. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Burn injury must be less than 24 hours old at time of initial sampling
• Burn must be 2nd or 3rd degree and at least 10% TBSA
• ISS (injury severity score) > 15

You may not qualify if…

• Burn injury/trauma injury > than 24hours old at time of initial sampling
• Burn < 10% total body surface area.
• Evidence of active infection on admission in the burn subjects.
• < 19 years of age and > 70 years

Where it is running

• University of South Alabama Medical Center — Mobile, Alabama, United States (enrolling)

Full record on ClinicalTrials.gov

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