The Use of Microneedles in Photodynamic Therapy

Completed · Not applicable

Conditions studied: Actinic Keratosis

In brief

The global aim of this study is to investigate how microneedles can facilitate the penetration and efficacy of photodynamic therapy in the treatment of actinic keratoses The specific aims are as follows: 1. Investigate whether pretreatment with microneedles enhances penetration of topical aminolevulinic acid (ALA) that is marketed as Levulan® Kerasticks by DUSA pharmaceuticals Inc. 2. Investigate whether pretreatment with microneedles can decrease the required incubation times of the topical ALA prior to exposure to blue light photodynamic therapy.

Key facts

Study ID

NCT01812837

Run by

University of California, Davis

People needed

51

Starts

2012-07-01

Expected to finish

2014-03-01

Last updated by the study team

2017-06-15

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Subjects who are 18 and older
• Subjects who have at least 3 actinic keratoses on each side of the forehead
• Subjects who signed an IRB approved informed consent

You may not qualify if…

• Subjects who smoke
• Subjects who have a photosensitizing condition such as lupus, porphyria, or similar condition.
• Subjects who received a diagnosis of skin cancer on the face in past year
• Subjects who received field treatment for actinic keratoses to the face in the past 60 days

Where it is running

• UC Davis, Dermatology — Sacramento, California, United States

Full record on ClinicalTrials.gov

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