Dexamethasone for Post-cesarean Delivery Pain

Completed · Phase 4 · Has a placebo group

Conditions studied: Pain, Postoperative, Postoperative Nausea and Vomiting

In brief

The purpose of this study is to compare post-cesarean section consumption of pain medication between two groups of patients undergoing scheduled cesarean section at term gestation who receive a single-dose of intraoperative steroid (dexamethasone 8 milligrams) versus placebo at 24 hours after surgery. The hypothesis is that a single perioperative dose of dexamethasone 8 mg will significantly reduce postoperative opioid consumption at 24 h in women having cesarean delivery under spinal anesthesia.

Key facts

Study ID

NCT01812057

Run by

Duke University

People needed

53

Starts

2012-12-01

Expected to finish

2016-09-21

Last updated by the study team

2017-07-25

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• American Society of Anesthesiology (ASA) class 1, 2 and 3
• Gestational age > 37 weeks
• scheduled for elective cesarean delivery
• spinal or combined spinal epidural anesthesia
• 18 years or older
• speak English

You may not qualify if…

• BMI > 45 kg/m2
• Diabetes Mellitus (Type 1, 2 and gestational)
• mild or severe preeclampsia
• history of intravenous drug or opioid abuse
• previous history of chronic pain syndrome
• history of opioid use in the past week
• receipt of an antiemetic within 24 h prior to surgery
• Non-English speaking

Where it is running

• Duke University Medical Center — Durham, North Carolina, United States

Full record on ClinicalTrials.gov

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