Impact of PAV Versus NAVA on Patient-Ventilator Synchrony and Respiratory Muscle Unloading

Withdrawn before enrolling · Not applicable

Conditions studied: Respiratory Failure

In brief

The purpose of this study is to determine whether two modes of artificial (i.e. mechanical) ventilation have an impact on patient synchrony with the ventilator (breathing machine) and on the patient's work of breathing.

Key facts

Study ID

NCT01810510

Run by

Massachusetts General Hospital

People needed

0

Starts

2010-04-01

Expected to finish

2016-09-01

Last updated by the study team

2016-11-07

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18 years or older
• Respiratory failure requiring mechanical ventilation
• Spontaneously breathing (able to generate flow/ pressure/ volume triggers on control modes of ventilation or on a mode of mechanically assisted spontaneous breathing)
• Requiring FiO2< 60% and PEEP< 10cm H2O to maintain oxygen saturations >90%

You may not qualify if…

• Pregnancy
• Inability to tolerate spontaneous breathing
• Gastro-esophageal pathology (including but not limited to recent gastric or esophageal surgery, history of varices, known anatomical gastric or esophageal defects such as strictures, hernias or fistulas)
• Agitation necessitating major sedative infusions
• Hemodynamic instability necessitating active adjustments in vasopressor therapy
• Coagulopathy
• New intracranial pathology (stroke, hemorrhage, meningitis, encephalitis)
• Paralyzed diaphragm

Where it is running

• Massachusetts General Hospital — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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