Neural Functioning of Feeding Centers in Obese Youth

Completed

Conditions studied: Obesity, Insulin Resistance

In brief

To explore whether obese adolescents with insulin resistance and relative low leptin levels exhibit functional alterations of the neuronal circuits involved in the regulation of energy metabolism and food seeking behaviors. We here propose to test the hypothesis that the reward circuitry is dysregulated in obese adolescents and is related to the degree of insulin resistance and hyperinsulinemia.

Key facts

Study ID

NCT01808846

Run by

Yale University

People needed

51

Starts

2010-07-01

Expected to finish

2017-02-01

Last updated by the study team

2017-04-27

Who can join

Age: 12 and older, up to 17. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Obese adolescents
• Good general health,
• taking no medication on a chronic basis
• Age 12 to 17 yrs,
• in puberty (girls and boys: Tanner stage II - IV)
• Obese Insulin Resistant Adolescents
• (BMI> 95th)
• (WBISI<1.2 plus a low adiponectin <6 ug/dl and
• high triglyceride levels >130mg/dl)
• Obese Insulin Sensitive Adolescents
• (BMI>95th)
• (WBISI >3) plus high adiponectin >8 ug/ml and
• triglyceride levels > 80 mg/dl Girls who begin menstruating must have a negative pregnancy test during the study
• Eligibility criteria for healthy non-obese children and adolescents:
• Brother or sister with obesity
• Age 12 to 17 years
• Normal fasting glucose and lipids in the child, and
• normal OGTT
• No use of any medication known to affect glucose, lipid metabolism and inflammation
• No endocrinopathies
• No use of any antipsychotic medication
• BMI >25th to <75th ( Center for Disease Control (CDC) BMI Charts)
• Minimum weight of 90lbs (CDC Growth Charts)

You may not qualify if…

• Baseline creatinine >1.0 mg
• Pregnancy
• Presence of endocrinopathies (e.g. Cushing syndrome)
• Cardiac or pulmonary or other significant chronic illness
• Adolescents with psychiatric disorder or with substance abuse determined via self-report.
• Use of anorexic agents No metal implants

Where it is running

• Yale University — New Haven, Connecticut, United States

Full record on ClinicalTrials.gov

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