Treatment of Meibomian Gland Dysfunction Prior to Cataract Surgery

Completed · Not applicable

Conditions studied: Blepharitis, Dry Eye Syndrome

In brief

The purpose of this pilot feasibility study is to assess whether treating meibomian gland dysfunction (MGD) prior to cataract surgery helps promote meibomian gland function, visual quality and ocular comfort after cataract surgery.

Key facts

Study ID

NCT01808560

Run by

TearScience, Inc.

People needed

34

Starts

2013-03-01

Expected to finish

2015-01-01

Last updated by the study team

2018-09-04

Who can join

Age: 55 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 55 to 85 years of age
• Must be able to comply with protocol including study randomization; completion of planned bilateral cataract surgery; no use of other MGD or dry eye treatments during the study; and attendance at all study visits
• Meibomian gland dysfunction in both eyes based on total meibomian gland score
• None to mild dry eye symptoms based on Ocular Surface Disease Index score
• Tear film interferometry assessment of 100 units or less

You may not qualify if…

• Systemic disease conditions that causes dry eye
• Use of systemic medications known to cause dry eye
• Use of other MGD or dry eye treatments except for over the counter lubricants or dietary supplements
• History of any of the following ocular conditions in the past 3 months: surgery, trauma, Herpes infection, recurrent inflammation, punctal plug insertion or punctal occlusion
• Presence of any of the following active conditions: ocular infection, ocular inflammation, moderate to severe allergic conjunctivitis, severe eyelid inflammation, eyelid abnormality that affects lid function, or ocular surface abnormality that compromises corneal integrity
• Participation in another ophthalmic drug or device trial in the past month

Where it is running

• Chicago Cornea Consultants, Ltd. — Hoffman Estates, Illinois, United States
• Jackson Eye — Lake Villa, Illinois, United States
• Charles River Eye Associates — Winchester, Massachusetts, United States
• Associated Eye Care — Stillwater, Minnesota, United States
• Ophthalmology Consultants, Ltd. — St Louis, Missouri, United States
• The May Eye Care Center — Hanover, Pennsylvania, United States
• Carolina EyeCare Physicians, LLC — Mt. Pleasant, South Carolina, United States

Full record on ClinicalTrials.gov

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