Global Profiling of Gene and Protein Expression Associated With Coronary Heart Disease Reversal

Completed · Not applicable

Conditions studied: Heart Diseases, Cardiovascular Diseases

In brief

The purpose of this study is to characterize changes in gene and protein expression in peripheral blood in patients with, or at risk for, heart disease during an intensive lifestyle modification program.

Key facts

Study ID

NCT01805492

Run by

Windber Research Institute

People needed

422

Starts

2000-01-01

Expected to finish

2009-02-01

Last updated by the study team

2013-03-06

Who can join

Age: 21 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• diagnosis of coronary artery disease (CAD)
• stable angina
• angioplasty
• evidence of >50% luminal narrowing on coronary angiogram
• acute myocardial infarction
• bypass surgery
• stent placement OR
• two or more CAD risk factors
• systolic pressure >140 mm Hg or diastolic pressure >90 mm Hg)
• high total cholesterol (>200 mg/dL)
• physician diagnosed diabetes
• body mass index (BMI) >30
• family history of heart disease in parents or siblings
• 21 years of age or older
• mentally competent to provide informed consent

You may not qualify if…

• known history of autoimmune disease
• systemic/chronic disease requiring chemotherapy or long term treatment

Where it is running

• Windber Medical Center — Windber, Pennsylvania, United States

Full record on ClinicalTrials.gov

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