A Screening Study to Detect BRAF V600 Mutation-Positive Patients For Enrollment Into Clinical Research Studies of Zelboraf (Vemurafenib)

Completed

Conditions studied: Multiple Myeloma, Neoplasms

In brief

This is a screening study to detect BRAF V600 mutation-positive patients for enrollment into clinical research studies of Zelboraf (vemurafenib). Tumor samples will be collected and analyzed from eligible patients with solid tumors (other than metastatic melanoma or papillary thyroid cancer) or multiple myeloma. All institutions with identified patients as defined by this screening protocol will have potential access to the separate vemurafenib protocol MO28072.

Key facts

Study ID

NCT01804140

Run by

Genentech, Inc.

People needed

662

Starts

2012-12-01

Expected to finish

2013-09-01

Last updated by the study team

2016-11-02

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Histologically confirmed solid tumors (excluding melanoma and papillary thyroid cancer) or multiple myeloma refractory to standard therapy or for which standard or curative therapy does not exist or is not considered appropriate by the investigator
• Patients with multiple myeloma must have received at least one line of prior systemic therapy for the treatment of multiple myeloma

You may not qualify if…

• Eastern Cooperative Oncology Group (ECOG) performance status > 2
• Uncontrolled concurrent malignancy
• Active or untreated CNS metastases
• History of known carcinomatous meningitis
• Prior treatment with a BRAF or MEK inhibitor (prior sorafenib is allowed)
• Uncontrolled, severe medical illness or condition as defined in protocol MO28072

Where it is running

• Study site — Sedona, Arizona, United States
• Study site — Tucson, Arizona, United States
• Study site — Burbank, California, United States
• Study site — Rancho Cucamonga, California, United States
• Study site — Denver, Colorado, United States
• Study site — Ocala, Florida, United States
• Study site — Woodbury, Minnesota, United States
• Study site — Columbia, Missouri, United States
• Study site — Las Vegas, Nevada, United States
• Study site — Nashville, Tennessee, United States
• Study site — Amarillo, Texas, United States
• Study site — Austin, Texas, United States
• Study site — Dallas, Texas, United States
• Study site — Dallas, Texas, United States
• Study site — Dallas, Texas, United States
• Study site — Denton, Texas, United States
• Study site — McAllen, Texas, United States
• Study site — Tyler, Texas, United States
• Study site — Spokane, Washington, United States
• Study site — Yakima, Washington, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.