Prognostic Value of PIF Detection in Embryo Culture Media Correlation With Pregnancy Outcome
Status unconfirmed
Conditions studied: Pregnancy, Fertility
In brief
PIF: biomarker of successful implantation To overcome the poor reproductive potential of embryos generated during in vitro fertilization cycles and the lack of markers enabling the identification of the most competent ones, it is common to transfer multiple embryos. However this practice is associated with the risks of multi-fetal pregnancies and high morbidity/mortality. Ideally, the availability of a marker specifically produced by viable embryos would permit the transfer of a single embryo (SET) without affecting the chances of pregnancy and, most importantly, capable to drastically reduce multiple pregnancies after IVF. In preliminary work, we demonstrated that no pregnancy resulted following the transfer of embryos where PIF was undetectable in culture media.(Keramitsoglou, T et al. ASRI Meeting, Hamburg, 2012) Using a non-invasive method of detection of PIF in the media surrounding the embryo will be correlated to live birth following single embryo transfer. By selecting only viable embryos, it will reduce the need for multiple IVF cycles, increase the rate of pregnancy outcome associated with SET, and will minimize multi-fetal pregnancy that has very high medical and societal costs both in pregnancy and after delivery.
Key facts
- Study ID
- NCT01803893
- Run by
- BioIncept LLC
- People needed
- 500
- Starts
- 2012-09-01
- Last updated by the study team
- 2013-03-04
Who can join
Age: 18 and older. Sex: female. Healthy volunteers: not accepted.
You may qualify if…
- All women included in our centers for classical IVF or ICSI, who will sign the written consent to participate in the study. PIF level evaluation in culture media (M) and pregnancy prognosis (S1 and S2) will be done only for women with SET.
- Exclusion criteria Women who will refuse to participate in the program.
Where it is running
- Yale Women and Children's Center for Blood Disorders & Yale Fertility Center — New Haven, Connecticut, United States
- Poissy St Germain Hospital — Poissy, Cedex, France
- Lab Clement - Seine St. Denis Hospital, Le Blanc Mesnil — Paris, France
- Versailles St. Quentin University — Poissy, France
- Helena Venizelou Hospital — Athens, Greece
Full record on ClinicalTrials.gov
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