Glucagon-like Peptide 1, Glucose Metabolism and Gastric Bypass

Recruiting now · Early Phase 1

Conditions studied: Post-bariatric Surgery

In brief

The overall goal of this project is to understand the mechanisms by which gastric bypass surgery improves glucose metabolism. The central hypothesis guiding this project is that the reconfiguration of intestinal transit with the Roux-en-Y will increase the release of insulinotropic GI hormones, termed incretins that improve insulin secretion and glucose metabolism. The study is divided into three specific aims. 1. To determine the role of incretin hormones on insulin secretion in patients with gastric bypass surgery using intravenous-oral hyperglycemic clamp. 2. To compare incretin effect and glucose tolerance among patient who suffer from hypoglycemia after RYGB and asymptomatic surgical and non-surgical individuals. 3. To quantify the contribution of GLP-1 to incretin effect enhancement following surgery.

Key facts

Study ID

NCT01803451

Run by

The University of Texas Health Science Center at San Antonio

People needed

80

Starts

2005-11-01

Expected to finish

2027-08-01

Last updated by the study team

2025-09-09

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• age 18-65
• healthy control without diabetes or active organ disease
• Individuals with bariatric surgery
• recurrent hypoglycemia post gastric bypass

You may not qualify if…

• pregnancy
• significant anemia
• diabetes currently unless pre-op for bariatric surgery procedure
• GI obstruction

Where it is running

• Texas Diabetes Institute - University Health System — San Antonio, Texas, United States (enrolling)
• South Texas Veterans Health Care System — San Antonio, Texas, United States (enrolling)

Full record on ClinicalTrials.gov

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