Memory Consolidation in Obstructive Sleep Apnea

Completed · Not applicable

Conditions studied: Obstructive Sleep Apnea

In brief

The overarching goal of the research proposed here is to test the hypothesis (i) that the pathophysiological mechanisms of OSA lead to deterioration in sleep-dependent memory consolidation across memory systems, with the genetic marker APOε4 as a modulator, and (ii) that CPAP can reverse some or all of these measured memory deficits. In addition, we are exploring which aspects of OSA (e.g., changes in sleep architecture, measures of hypoxemia, or the EEG power spectrum) most likely impact sleep-dependent memory processing.To this end, we are using specific cognitive tasks for which sleep-dependent memory consolidation processes have previously been demonstrated by our group and others. In addition, we are carrying out quantitative EEG power spectral analyses, to delineate abnormal functioning of brain regions with more precision.

Key facts

Study ID

NCT01800786

Run by

Brigham and Women's Hospital

People needed

33

Starts

2011-08-01

Expected to finish

2016-06-30

Last updated by the study team

2017-06-06

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: accepted.

You may not qualify if…

• ALL PARTICIPANTS:
• Potential participants (OSA patients and controls) are excluded if one or more of the following conditions are found:
• Any history of clinically significant, uncontrolled medical or psychiatric condition (treated or untreated), other than OSA and hypertension (self-report)
• History of serious heart disease or renal failure (self-report)
• History of head injury (self-report)
• Inability to type (e.g., physical disability, arthritis) or to exercise
• A lifetime history of alcohol, narcotic or any other drug abuse (self-report)
• Use of medications, over-the counter drugs or nutritional supplements known to have an effect on sleep, cognition and/or daytime vigilance (self-report)
• Female subjects who are pregnant cannot take part in the study. If a female subject becomes pregnant during the study, she will have to stop participation
• Presence of any of the following sleep disorders:
• Cheyne-Stokes breathing or central sleep apnea (> 10% of events central) (screening sleep study)
• Circadian rhythm disorder (structured interview)
• REM sleep without atonia or REM behavior disorder (structured interview and screening sleep study )
• Parasomnias (structured interview)
• PLMS index of >15/h (screening sleep study)
• Insomnia (structured interview and 2 weeks sleep diaries)
• Narcolepsy (structured interview)
• Left-handedness (only MSLT participants)- (self-report)
• uncorrected vision impairment and/or visual field defect (self report, screening examination)

Where it is running

• Brigham and Women's Hospital — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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