Endometrial Biopsy Prior to IVF in Those Patients With Prior Implantation Failure
Status unconfirmed · Not applicable · Has a placebo group
Conditions studied: Implantation Failure, Infertility
In brief
This proposed research is a single center, prospective, single-blinded, randomized controlled trial, designed to evaluate IVF pregnancy outcomes following endometrial injury in 254 patients with implantation failure. Patients will be identified during their work-up and treatment at Shady Grove Fertility Reproductive Science Center. Only Shady Grove patients are eligible for the study. The investigators hypothesize in patients with one or more previous failed day 5 blastocyst transfers, injury to the endometrium via endometrial biopsy will improve clinical pregnancy outcomes compared to controls.
Key facts
- Study ID
- NCT01800513
- Run by
- Shady Grove Fertility Reproductive Science Center
- People needed
- 254
- Starts
- 2013-02-01
- Expected to finish
- 2015-12-01
- Last updated by the study team
- 2013-02-27
Who can join
Age: 18 and older, up to 37. Sex: female. Healthy volunteers: not accepted.
You may qualify if…
- Women age 18-37
- One or more previous implantation failures with autologous fresh or frozen blastocyst transfer
- Undergoing fresh autologous IVF cycle
- No other current uterine (i.e.: uterine fibroids, polyps), hematologic, or genetic causes for infertility and implantation failure
- One or more good quality blastocyst(s) available for transfer
You may not qualify if…
- Those unable to comprehend the investigational nature of the proposed study
- Positive pregnancy test
- Possible causes for impaired implantation (systemic disease, endometriosis, ultrasound evidence of current hydrosalpinx, uterine polyps, uterine myomas (fibroids), uterine cavity malformations or Asherman's syndrome)
- Poor responders, defined as FSH >12 on day 3 or less than 4 follicles on a previous IVF cycle
- BMI >30 or <18
Where it is running
- Shady Grove Fertility Reproductive Science Center — Rockville, Maryland, United States (enrolling)
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.