Characterization of LV Strain Patterns in Mildly Elevated PCWP and PAH.

Completed · Phase 4

Conditions studied: Hypertension, Pulmonary Artery, Ventricular Dysfunction, Left

In brief

The purpose of this study is to determine if patients with pulmonary hypertension and mildly elevated heart pressure known as PCWP will exhibit different patterns on echocardiography and that these patterns will predict treatment response to sildenafil, a drug given for this condition.

Key facts

Study ID

NCT01800292

Run by

University of Arizona

People needed

9

Starts

2013-02-01

Expected to finish

2014-12-01

Last updated by the study team

2015-11-04

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with New York Heart Association/World Health Organization(NYHA/WHO)functional class II-III
• Patients with mean pulmonary artery pressure >25 mmHg, pulmonary capillary wedge pressure >15 mmHg ≤18, and pulmonary vascular resistance >3 wood units
• Age >18 and <80
• Stable on antihypertensives and diuretics>3 months
• No evidence of active ischemic heart disease
• 6 minute walk distance >150 meters and <450 meters

You may not qualify if…

• - Left ventricular ejection fraction <50%
• Patients with significant restrictive lung disease (FVC<60% predicted) and/or significant obstructive lung disease (FEV1 <55% predicted) within 1 year of enrollment
• Poorly interpretable grey scale echocardiographic images
• Contraindications to right heart catheterization
• Nitroglycerin therapy
• Moderate-severe aortic and mitral valve abnormality
• Contraindications to submaximal exercise testing

Where it is running

• University of Arizona Medical Center — Tucson, Arizona, United States

Full record on ClinicalTrials.gov

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