Study to Evaluate Efficacy, Safety, Tolerability, and Pharmacodynamics of Entospletinib in Adults With Relapsed or Refractory Hematologic Malignancies
Stopped early · Phase 2
Conditions studied: Chronic Lymphocytic Leukemia, Mantle Cell Lymphoma, Diffuse Large B-cell Lymphoma, Non-FL Indolent Non-Hodgkin's Lymphoma, Follicular Lymphoma
In brief
The primary objective of the study is to evaluate efficacy of entospletinib in participants with relapsed or refractory hematologic malignancies. Participants with the following relapsed or refractory hematologic malignancies will be enrolled into the study: relapsed or refractory chronic lymphocytic leukemia (CLL), mantle cell lymphoma (MCL), diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), or non-FL indolent non-Hodgkin lymphomas (iNHL; including lymphoplasmacytoid lymphoma/ Waldenström macroglobulinemia \[LPL/WM\], small lymphocytic lymphoma \[SLL\], or marginal zone lymphoma \[MZL\]).
Key facts
- Study ID
- NCT01799889
- Run by
- Gilead Sciences
- People needed
- 326
- Starts
- 2013-03-14
- Expected to finish
- 2020-01-30
- Last updated by the study team
- 2020-11-19
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- University of Alabama at Birmingham — Birmingham, Alabama, United States
- Arizona Oncology Associates — Tucson, Arizona, United States
- City of Hope National Medical Center — Duarte, California, United States
- Sharp Memorial Hospital — San Diego, California, United States
- Rocky Mountain Cancer Centers, LLP — Boulder, Colorado, United States
- Kaiser Permanente of Colorado — Denver, Colorado, United States
- Cancer Center of Central Connecticut — Southington, Connecticut, United States
- Florida Cancer - Colonial — Fort Myers, Florida, United States
- Memorial Cancer Institute — Hollywood, Florida, United States
- Ocala Oncology Center — Ocala, Florida, United States
- Northside Hospital — Atlanta, Georgia, United States
- Gwinnett Hospital System Dba The Center for Cancer Care — Lawrenceville, Georgia, United States
- Northwest Georgia Oncology Center — Marietta, Georgia, United States
- University of Chicago — Chicago, Illinois, United States
- Illinois Cancer Specialists — Niles, Illinois, United States
- Indiana University Simon Cancer Center — Indianapolis, Indiana, United States
- Hematology Oncology Clinic, PLLC — Baton Rouge, Louisiana, United States
- Tufts Medical Center — Boston, Massachusetts, United States
- University of Michigan Health System — Ann Arbor, Michigan, United States
- Karmanos Cancer Institute — Detroit, Michigan, United States
- Minnesota Oncology Hematology, PA — Minneapolis, Minnesota, United States
- Hattiesburg Clinic — Hattiesburg, Mississippi, United States
- Oncology Hematology West PC dba Nebraska Cancer Specialists — Omaha, Nebraska, United States
- One Medical Center Drive — Lebanon, New Hampshire, United States
- Summit Medical Group, P.A. — Florham Park, New Jersey, United States
Full record on ClinicalTrials.gov
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