Use of Cell Therapy to Enhance Arthroscopic Knee Cartilage Surgery

Completed · Not applicable

Conditions studied: Articular Cartilage Defect Grade III or IV of the Knee

In brief

The purpose of this study is to assess the potential benefit of enhancing knee surgery for cartilage injury using some of the patient's own cells, taken from fat tissue, that may be able to help cartilage to regenerate.

Key facts

Study ID

NCT01799876

Run by

Fondren Orthopedic Group L.L.P.

People needed

48

Starts

2013-02-01

Expected to finish

2017-08-01

Last updated by the study team

2019-01-10

Who can join

Age: 18 and older, up to 68. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subjects undergoing microfracture surgery for the repair of articular cartilage
• Osteochondral defect Grade III or IV
• Age 18 to 68 years
• Sufficient subcutaneous adipose tissue to yield 20-30 cc of lipoaspirate
• Written informed consent
• Ability to speak, read and write English or Spanish

You may not qualify if…

• Inability to speak, read and write English or Spanish
• Evidence of malignant disorder/neoplasm in past 24 months
• History of basal cell carcinoma
• History of smoking and not committed to give up
• Chronic skin conditions
• Connective, metabolic or skin disease
• Evidence of active infection
• Pregnancy or lactating for female subjects
• Diabetes Type I or II
• Current steroid use
• Immunosuppressive medication
• Renal failure (creatine > 1.8 mg/dL)
• Hepatic failure (AST, ALT >2 times normal values; bilirubin >2.0 mg/dL)
• Inflammatory joint diseases of the knee that indicate additional, conflating therapies
• Joint infection within the past 6 months
• Meniscal resection of greater than 50% prior to, or at time of procedure
• Uncorrected joint instability
• Joint malalignment > 5 degrees

Where it is running

• Fondren Orthopedic Group, L.L.P. — Houston, Texas, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.