A Phase 3 Study of Ganetespib in Combination With Docetaxel Versus Docetaxel Alone in Patients With Advanced NSCLC
Stopped early · Phase 3
Conditions studied: Non-Small-Cell Lung Adenocarcinoma, Non-small Cell Lung Cancer Stage IIIB, Non-small Cell Lung Cancer Stage IV, Non-small Cell Lung Cancer Metastatic
In brief
The purpose of this study is to determine whether combining ganetespib (STA-9090) with docetaxel is more effective than docetaxel alone in the treatment of patients with advanced non-small cell lung cancer.
Key facts
- Study ID
- NCT01798485
- Run by
- Synta Pharmaceuticals Corp.
- People needed
- 696
- Starts
- 2013-04-01
- Expected to finish
- 2015-12-01
- Last updated by the study team
- 2016-07-01
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Advanced Stage IIIB or IV non-small-cell lung cancer (NSCLC)
- Eastern Oncology Cooperative Group (ECOG) Performance Status 0 or 1
- Prior therapy defined as 1 prior systemic therapy for advanced disease
- Documented disease progression during or following most first line therapy for advanced disease
- Adequate hematologic, hepatic, renal function
You may not qualify if…
- Epidermal growth factor receptor (EGFR) mutations
- Anaplastic lymphoma kinase (ALK) translocations
- Predominantly squamous, adenosquamous or unclear histologic type
- Active or untreated central nervous system (CNS) metastases
- Active malignancies other than NSCLC within the last 5 years with the exception of adequately treated cone-biopsied in situ carcinoma of the cervix uteri or basal or squamous cell carcinoma of the skin
- Serious cardiac illness or medical conditions
- Pregnant or lactating women
- Uncontrolled intercurrent illness
Where it is running
- Arizona Oncology Associates, PC- NAHOA — Prescott Valley, Arizona, United States
- Northern Arizona Hematology & Oncology Associates — Sedona, Arizona, United States
- Arizona Clinical Research Center, Inc. — Tucson, Arizona, United States
- Pacific Cancer Medical Center, Inc — Anaheim, California, United States
- Comprehensive Blood & Cancer Center — Bakersfield, California, United States
- City of Hope Comprehensive Breast Cancer Center — Duarte, California, United States
- UC San Diego Moores Cancer Center — La Jolla, California, United States
- Loma Linda University Cancer Center — Loma Linda, California, United States
- VA Greater Los Angeles Healthcare System — Los Angeles, California, United States
- Ronald Reagan UCLA Medical Center — Los Angeles, California, United States
- St. Joseph Hospital, Center for Cancer Prevention and Treatment — Orange, California, United States
- Cancer Care Associates Medical Group, Inc. — Redondo Beach, California, United States
- UC Davis Medical Center - UC Davis Comprehensive Cancer — Sacramento, California, United States
- Santa Barbara Hematology Oncology Medical Group, Inc. — Santa Barbara, California, United States
- City of Hope- South Pasadena — South Pasadena, California, United States
- Rocky Mountain Cancer Center — Denver, Colorado, United States
- Eastern Connecticut Hematology Associates — Norwich, Connecticut, United States
- Medical Oncology Hematology Consultants, PA — Newark, Delaware, United States
- Lynn Cancer Institute Center for Hematology Oncology — Boca Raton, Florida, United States
- Halifax Health - Medical Center — Daytona Beach, Florida, United States
- University of Miami Health System Sylvester at Deerfield Beach — Deerfield Beach, Florida, United States
- Memorial Regional Hospital — Hollywood, Florida, United States
- Baptist Health Medical Group Oncology, LLC — Miami, Florida, United States
- University of South Florida - H. Lee Moffitt — Tampa, Florida, United States
- Arizona Oncology Associates PC- NAHOA — Flagstaff, Arizona, United States
Full record on ClinicalTrials.gov
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