Vitamin D Retrospective Study and Role With Disease

Status unconfirmed

Conditions studied: Vitamin D Status, Glucose Tolerance, Blood Pressure, Bone Mineral Density, Hyperlipidemia

In brief

Vitamin D deficiency is associated with a heightened risk for developing type 2 diabetes, hypertension, and osteopenia/osteoporosis. Vitamin D is made in the skin when it is exposed to sunlight and it is also obtained from the diet and dietary supplements. Older people, individuals with high skin pigmentation, obese and sedentary individuals have low levels of Vitamin D because pigmentation blocks Vitamin D production in the skin, aging and physical inactivity are associated with reduced exposure to sunlight, and obesity is associated with the storage of Vitamin D in fat preventing its utilization by muscle, bone and other tissues that require its metabolic action. These conditions are also associated with heightened risk for developing type 2 diabetes, glucose intolerance, hypertension, and osteopenia/osteoporosis in older and obese individuals. This is particularly heightened in older women who tend to have increased body fat, are more physically inactive and are at high risk for central obesity and its metabolic consequences of diabetes, hypertension and osteoporosis.

Key facts

Study ID
NCT01798030
Run by
Baltimore VA Medical Center
People needed
362
Starts
2009-11-01
Expected to finish
2022-12-01
Last updated by the study team
2021-07-20

Who can join

Age: 45 and older, up to 85. Sex: any. Healthy volunteers: accepted.

Where it is running

Full record on ClinicalTrials.gov

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