A Comparison of the Metabolic Effects of Fructose, Glucose, High Fructose Corn Syrup and Sucrose at Normal Population Consumed Levels in Adults Aged 20-60 Years Old

Completed · Not applicable

Conditions studied: Obesity

In brief

The purpose of this study is to investigate the acute and chronic effects of consumption fructose containing sugars and glucose in a real word setting when consumed in a manner and amount typical in the American diet.

Key facts

Study ID

NCT01797042

Run by

Rippe Lifestyle Institute

People needed

366

Starts

2012-03-01

Expected to finish

2014-07-01

Last updated by the study team

2014-09-30

Who can join

Age: 20 and older, up to 60. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Body Mass Index (BMI) 21.0 -33.0

You may not qualify if…

• More than a 3% change in weight within the 3 months prior to enrollment in the study.
• Currently smoking cigarettes
• Currently taking any prescription medication for less than 3 months.
• Currently taking a prescription medication for weight loss (4 week wash out period required).
• Currently taking any over-the-counter weight loss supplement/s (2 week wash out period required).
• History of thyroid disease, but not taking medication or medication dosage changed one or more times over last 6 months.
• Diagnosed with Type I or Type II diabetes or prediabetes.
• Major surgery within three months of enrollment.
• History of heart problems (e.g. angina, bypass surgery, MI, etc.) within three months prior to enrollment.
• Presence of implanted cardiac defibrillator or pacemaker.
• Uncontrolled hypertension/high blood pressure.
• History of a surgical procedure for weight loss at any time.
• Gastrointestinal disorders including chronic malabsorptive conditions, peptic ulcer disease, Crohn's disease, chronic diarrhea or active gallbladder disease.
• History of inflammatory bowel disease
• History of fatty liver
• History or presence of cancer (except for successfully resected basal cell carcinoma of the skin more than 6 months prior to enrollment).
• History of clinically diagnosed eating disorders including anorexia nervosa, bulimia nervosa or binge eating disorder.
• Women who are pregnant, lactating or trying to become pregnant.
• History of alcohol dependency
• Currently consuming >14 alcoholic drinks (1 drink = 12 fl oz beer, 4 fl oz wine or 1.5 fl oz liquor) per week and/or unwilling to limit intake to less than 3 drinks per week during study participation.
• Lactose intolerance
• Known allergy to HFCS, sucrose, fructose or glucose.
• Any clinically significant food allergy
• Participation in another clinical trial within 30 days prior to enrollment.

Where it is running

• Rippe Lifestyle Institute — Celebration, Florida, United States

Full record on ClinicalTrials.gov

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