Ketogenic Diet for Refractory Status Epilepticus
Completed · Not applicable
Conditions studied: Status Epilepticus, Seizure, Epilepsy, Refractory Status Epilepticus, Medically Resistant Status Epilepticus
In brief
This research is being done to observe the safety, tolerability, side effects, and effectiveness of the ketogenic diet in people with continuous seizures (status epilepticus) being treated in a neurointensive care unit.
Key facts
- Study ID
- NCT01796574
- Run by
- Johns Hopkins University
- People needed
- 15
- Starts
- 2012-11-01
- Expected to finish
- 2017-03-01
- Last updated by the study team
- 2017-03-14
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients 18 years and older in refractory status epilepticus (continuous or recurrent seizures without return to baseline mental status between seizures, lasting > 30 minutes) placed on anesthetics/sedating agents (barbiturates or benzodiazepines) after at least one first- and second-line agent failed to control seizures, and with clinical and/or electrographic seizures following attempt to wean anesthetic/sedating agents after 24 hours.
You may not qualify if…
- Unstable metabolic condition
- Hemodynamic or cardiorespiratory instability
- Coagulopathy
- Liver failure
- Total cholesterol > 300 mg/dL
- Inability to tolerate enteral feeds, including ileus
- Pregnancy
- Family refusal/no consent
- Received any propofol infusions within 24 hours
- Known fatty acid oxidation disorder or pyruvate carboxylase deficiency
Where it is running
- Mayo Clinic — Phoenix, Arizona, United States
- Queen's Medical Center — Honolulu, Hawaii, United States
- Rush University Medical Center — Chicago, Illinois, United States
- Johns Hopkins University — Baltimore, Maryland, United States
- Mayo Clinic — Rochester, Minnesota, United States
- New York University — New York, New York, United States
- Oregon Health & Science University — Portland, Oregon, United States
- Thomas Jefferson University — Philadelphia, Pennsylvania, United States
- Intermountain Medical Center — Murray, Utah, United States
Full record on ClinicalTrials.gov
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