Entospletinib in Combination With Idelalisib in Adults With Relapsed or Refractory Hematologic Malignancies
Stopped early · Phase 2
Conditions studied: Chronic Lymphocytic Leukemia, Mantle Cell Lymphoma, Diffuse Large B-cell Lymphoma, Indolent Non-Hodgkin's Lymphoma
In brief
This study will evaluate the efficacy of the combination entospletinib and idelalisib in participants with relapsed or refractory hematologic malignancies. Participants will be enrolled who have one of the following hematological tumor types: chronic lymphocytic leukemia (CLL), mantle cell lymphoma (MCL), diffuse large B-cell lymphoma (DLBCL), or indolent non-Hodgkin lymphomas (iNHL; including follicular lymphoma (FL) and lymphoplasmacytoid lymphoma/Waldenström macroglobulinemia \[LPL/WM\], small lymphocytic lymphoma \[SLL\], or marginal zone lymphoma \[MZL\]).
Key facts
- Study ID
- NCT01796470
- Run by
- Gilead Sciences
- People needed
- 66
- Starts
- 2013-06-20
- Expected to finish
- 2016-12-22
- Last updated by the study team
- 2020-06-02
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- UC San Diego Moores Cancer Center — La Jolla, California, United States
- Pacific Shores Medical Group — Long Beach, California, United States
- Ventura County Hematology Oncology Specialists — Oxnard, California, United States
- Cancer Center of Santa Barbara — Santa Barbara, California, United States
- Georgetown University Medical Center — Washington D.C., District of Columbia, United States
- Collaborative Research Group LLC — Boynton Beach, Florida, United States
- Weill Cornell Medical College — New York, New York, United States
- University of Rochester, James P. Wilmot Cancer Center — Rochester, New York, United States
- Signal Point Clinical Research Center, LLC — Middletown, Ohio, United States
- Oregon Health and Science University — Portland, Oregon, United States
- Charleston Hematology Oncology — Charleston, South Carolina, United States
- MD Anderson Cancer Center — Houston, Texas, United States
- Northwest Medical Specialties — Tacoma, Washington, United States
Full record on ClinicalTrials.gov
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