Carotid Artery Neovascularization in Takayasu's and Giant Cell Arteritis

Completed

Conditions studied: Takayasu's Arteritis, Giant Cell Arteritis, Arteritis, Vasculitis, Aortitis

In brief

The purpose of this study is to evaluate the ability of contrast enhanced carotid ultrasound to serve as an indicator of disease activity in patients with Takayasu's arteritis or Giant Cell arteritis and to determine if patients with active arteritis have a thickening of their blood vessel walls compared to healthy people of the same age and gender.

Key facts

Study ID

NCT01795456

Run by

The Cleveland Clinic

People needed

7

Starts

2010-08-01

Expected to finish

2014-01-01

Last updated by the study team

2017-01-27

Who can join

Age: 18 and older, up to 100. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Male and female patients >18 years
• Diagnosis of Takayasu's arteritis or giant cell arteritis
• Suspicion of common carotid involvement on the basis of physical examination (cervical bruit), carotidynia, documented CCA involvement on an imaging study (MRA, CTA, or ultrasound), or documented upper extremity large vessel involvement on an imaging study (MRA or CTA or ultrasound).
• Ability to provide informed consent

You may not qualify if…

• Prior stroke, carotid surgery or angioplasty
• Pregnant (or trying to become pregnant)
• Nursing
• Known or suspected cardiac shunt
• Documented hypersensitivity to the contrast agent
• Severe pulmonary hypertension or unstable cardiopulmonary conditions (acute myocardial infarction, acute coronary artery syndromes, worsening or unstable congestive heart failure, serious ventricular arrhythmias, or respiratory failure)

Where it is running

• Cleveland Clinic Main Campus, Section of Vascular Medicine — Cleveland, Ohio, United States

Full record on ClinicalTrials.gov

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