Effects of Transcranial Direct Current Stimulation (tDCS) on Neuropathic Symptoms Following Burn Injury
Completed · Not applicable · Has a placebo group
Conditions studied: Burn Injury, Chronic Pain, Pruritus, Itching
In brief
The purpose of this study is to see the effects of transcranial direct current stimulation (tDCS) on the pain and itching associated with burn injury. This study is part of the Boston-Harvard Burn Model System. The investigators hypothesize that there will be a decrease in pain levels with active stimulation, when compared to sham stimulation, using a 3 week stimulation schedule- 2 weeks of stimulation (10 consecutive days) followed by 1 week of stimulation (5 consecutive days) after three follow up visits at 2, 4 and 8 weeks after initial course of stimulation. The subject will also have follow ups at 2, 4 and 8 weeks after the second course of stimulation. If a subject receives sham during the experiment, he/she may enroll in an open-label portion of the study and receive 10 days of active stimulation.
Key facts
- Study ID
- NCT01795079
- Run by
- Spaulding Rehabilitation Hospital
- People needed
- 34
- Starts
- 2013-01-01
- Expected to finish
- 2020-04-15
- Last updated by the study team
- 2021-03-17
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Providing informed consent to participate in the study
- Age 18 or older
- Burn injury with pain and/or itch that is moderate to severe
- Burn injury occurring at least 3 weeks prior to enrollment
You may not qualify if…
- Subjects with burns in scalp in the area of electrode placement
- Psychiatric disorders that have led to hospitalization within the past 6 months or signs of suicidality
- Learning disorders that may prevent patient's ability to complete assessments
- Unstable conditions preventing travel to study site
- Current use of any of the following anti-epileptic medications or dopaminergic medications known to reduce or inhibit the benefits of tDCS treatment: carbamazepine, oxcarbazepine, phenytoin
- Contraindications to tDCS including implanted metal plates in the head or implanted brain medical devices
- Pregnancy at time of enrollment
- History of other neurological conditions associated with structural anatomical changes (i.e. stroke, brain injury, Parkinson's)
Where it is running
- Spaulding Rehabilitation Hospital — Boston, Massachusetts, United States
Full record on ClinicalTrials.gov
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